Enriched by the vast experience, we have been able to offer a range of high quality Triciribine CAS 35943-35-2. Triciribine CAS NO 35943-35-2 also known as API-2, NSC 154020 and Tricyclic Nucleoside that is a synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. Akt kinase inhibition has been shown to induce apoptosis and cell growth in cancer cell research. Triciribine 35943-35-2 is sterile level. Our standard is high specification. Customers can choose our product at ease. We also can offer effective service and the goods can be packaged in a proper way to meet customers requirement.

Thera. Category: Anti-cancer

Cas No.: 35943-35-2

Synonym: API-2;6-AMINO-4-METHYL-8-(BETA-D-RIBOFURANOSYL)-4H,8H-PYRROLO[4,3,2-DE]PYRIMIDO[4,5-C]PYRIDAZINE;AKT/PKB SIGNALING INHIBITOR-2;AKT INHIBITOR V;1,5-DIHYDRO-5-METHYL-1-BETA-D-RIBOFURANOSYL-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-3-AMINE;1,4,5,6,8-pentaazaacenaphthylen-3-amine,1,5-dihydro-5-methyl-1-beta-d-ribofura;1,4,5,6,8-pentaazaacenaphthylene,3-amino-1,5-dihydro-5-methyl-1-beta-d-ribof;3-amine

Molecular Formula: C13H16N6O4

Molecular Weight: 320.3

Assay: ≥99.%

Packing: Export worthy packing

lMaterial Safety Data Sheet: Available on request

Usage:  Triciribine 35943-35-2 , also known as API-2, suppresses the phosphorylation level and kinase activity of Akt. Akt kinase inhibition has been shown to induce apoptosis and cell growth in cancer cell research. Triciribine can selectively inhibit Akt1, Akt2, and Akt3 without inhibiting known upstream activators,PDK1 and PI 3-Kinase, of Akt. Studies show that Triciribine in duces apoptosis and inhibits cell growth in cells that express atypical Akt1. Additionally, Triciribine has antineoplastic and antiviral activity at low micromolar and submicromolar concentrations, and has been demonstrated to inhibit incorporation of amino acids into proteins and purine nucleotide synthesis.